TNF-alpha promoter polymorphism in relation to TNF-alpha production and clinical status in cystic fibrosis.

@article{SchmittGroh2006TNFalphaPP,
  title={TNF-alpha promoter polymorphism in relation to TNF-alpha production and clinical status in cystic fibrosis.},
  author={Sabina Schmitt-Groh{\'e} and Frank Stueber and M. Harold Book and Joachim Bargon and Thomas O. F. Wagner and Christian Naujoks and Ralf Schubert and Michael J. Lentze and Stefan Zielen},
  journal={Lung},
  year={2006},
  volume={184 2},
  pages={99-104}
}
The severity of lung disease in cystic fibrosis may be related to the genetic propensity of the host to produce tumor necrosis fector alpha (TNF-alpha). A polymorphism in the promoter region of the TNF-alpha gene at nucleotide 308 relative to the transcription start site may be important in determing the host's TNF-alpha response. The aim of this study was to assess the correlation between a TNF-308 promoter polymorphism, ex vivo TNF-alpha production (before and after lipopolysaccharide (LPS… CONTINUE READING