TNF-alpha pretreatment induces protective effects against focal cerebral ischemia in mice.

@article{Nawashiro1997TNFalphaPI,
  title={TNF-alpha pretreatment induces protective effects against focal cerebral ischemia in mice.},
  author={Hiroshi Nawashiro and Kazuyuki Tasaki and Christl A Ruetzler and John M. Hallenbeck},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={1997},
  volume={17 5},
  pages={
          483-90
        }
}
Cytokines are recognized to play an important role in acute stroke. Tumor necrosis factor-alpha (TNF) is one of the pro-inflammatory cytokines and is expressed in ischemic brain. We hypothesized that TNF might play a role in the regulation of tolerance to ischemia when administered prior to the ischemic episode. We studied the effects of pretreatment of TNF administered intravenously, intraperitoneally, or intracisternally in mice that were subjected to middle cerebral artery occlusion (MCAO… CONTINUE READING
Highly Cited
This paper has 273 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 117 extracted citations

Preischemic induction of TNF-alpha by physical exercise reduces blood-brain barrier dysfunction in stroke.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2008
View 5 Excerpts
Highly Influenced

The Janus Face of VEGF in Stroke

International journal of molecular sciences • 2018

273 Citations

01020'98'03'09'15
Citations per Year
Semantic Scholar estimates that this publication has 273 citations based on the available data.

See our FAQ for additional information.