TNF-alpha preserves lysosomal stability in macrophages: a potential defense against oxidative lung injury.

@article{Persson2010TNFalphaPL,
  title={TNF-alpha preserves lysosomal stability in macrophages: a potential defense against oxidative lung injury.},
  author={H L Persson and Linda K Vainikka},
  journal={Toxicology letters},
  year={2010},
  volume={192 2},
  pages={261-7}
}
Iron-catalyzed oxidative damage on the respiratory epithelium is prevented by alveolar macrophages depositing iron inside their lysosomes. Bound in an un-reactive state to various metalloproteins, e.g. ferritin, most lysosomal iron is kept separated from reactive oxygen species (ROS) by intracellular anti-oxidative enzyme systems. Some ROS may, however, escape this protective shield of antioxidants, react with small amounts of free redox-active iron within lysosomes, thereby causing… CONTINUE READING
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