TNF-alpha opens a paracellular route for HIV-1 invasion across the blood-brain barrier.

Abstract

BACKGROUND HIV-1 invades the central nervous system early after infection when macrophage infiltration of the brain is low but myelin pallor is suggestive of blood-brain-barrier damage. High-level plasma viremia is a likely source of brain infection. To understand the invasion route, we investigated virus penetration across in vitro models with contrasting… (More)

Topics

Cite this paper

@article{Fiala1997TNFalphaOA, title={TNF-alpha opens a paracellular route for HIV-1 invasion across the blood-brain barrier.}, author={Milan Fiala and Darrell Looney and Monique Fabienne Stins and Douglas Way and L. Zhang and Xiang Gan and Francesco Chiappelli and Eugene Schweitzer and Professor Paul Shapshak and Martin E. Weinand and Margot Graves and Maarten Witte and K. S. Kim}, journal={Molecular medicine}, year={1997}, volume={3 8}, pages={553-64} }