TNF-alpha mediates p38 MAP kinase activation and negatively regulates bone formation at the injured growth plate in rats.

UNLABELLED TNF-alpha is known to inhibit osteoblast differentiation in vitro and yet it is essential for bone fracture repair. Roles of TNF-alpha in the bony repair of injured growth plate were examined in young rats treated with a TNF-alpha antagonist. The results show that TNF-alpha mediates p38 activation, which influences the recruitment, proliferation… CONTINUE READING