TNF alpha is localized to nasal mucosal mast cells and is released in acute allergic rhinitis.

@article{Bradding1995TNFAI,
  title={TNF alpha is localized to nasal mucosal mast cells and is released in acute allergic rhinitis.},
  author={Peter Bradding and R Mediwake and I H Feather and Jeanne Madden and M K Church and Stephen T. Holgate and Peter Howarth},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={1995},
  volume={25 5},
  pages={406-15}
}
Allergic mucosal inflammation is characterized by tissue infiltration with eosinophils, and associated activation of mast cells and T lymphocytes. Tumour necrosis factor (TNF) alpha/cachectin is a candidate cytokine relevant to the pathogenesis of these events through its capacity to upregulate the expression of endothelial cell adhesion molecules, mediate granulocyte chemoattraction, and activate eosinophils, mast cells and T cells. To investigate the presence and localization of TNF alpha in… CONTINUE READING

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