TNF-alpha is critical to facilitate hemopoietic stem cell engraftment and function.

@article{Rezzoug2008TNFalphaIC,
  title={TNF-alpha is critical to facilitate hemopoietic stem cell engraftment and function.},
  author={Francine Rezzoug and Yiming Huang and Michael K. Tanner and Marcin Wysoczynski and Carrie L. Schanie and P. Chilton and Mariusz Z Ratajczak and Isabelle J. Fugier-Vivier and Suzanne T. Ildstad},
  journal={Journal of immunology},
  year={2008},
  volume={180 1},
  pages={49-57}
}
The use of tolerogenic cells as an approach to induce tolerance to solid organ allografts is being aggressively pursued. A major limitation to the clinical application of cell-based therapies has been the ability to obtain sufficient numbers and also preserve their tolerogenic state. We previously reported that small numbers of bone marrow-derived CD8+/TCR- graft facilitating cells (FC) significantly enhance hemopoietic stem cell (HSC) engraftment in allogeneic and syngeneic recipients… CONTINUE READING

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