TNF-alpha inhibition reduces renal injury in DOCA-salt hypertensive rats.

@article{Elmarakby2008TNFalphaIR,
  title={TNF-alpha inhibition reduces renal injury in DOCA-salt hypertensive rats.},
  author={Ahmed A. Elmarakby and Jeffrey E. Quigley and John D. Imig and Jennifer S. Pollock and David M Pollock},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2008},
  volume={294 1},
  pages={R76-83}
}
Studies suggest that the inflammatory cytokine TNF-alpha plays a role in the prognosis of end-stage renal diseases. We previously showed that TNF-alpha inhibition slowed the progression of hypertension and renal damage in angiotensin II salt-sensitive hypertension. Thus, we hypothesize that TNF-alpha contributes to renal inflammation in a model of mineralocorticoid-induced hypertension. Four groups of rats (n = 5 or 6) were studied for 3 wk with the following treatments: 1) placebo, 2) placebo… CONTINUE READING

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