TNF alpha induces expression of the chemoattractant cytokine RANTES in cultured mouse mesangial cells.

@article{Wolf1993TNFAI,
  title={TNF alpha induces expression of the chemoattractant cytokine RANTES in cultured mouse mesangial cells.},
  author={Gunter B Wolf and Silke Aberle and Friedrich Thaiss and Peter Jon Nelson and Alan M. Krensky and Eric G. Neilson and Rolf A K Stahl},
  journal={Kidney international},
  year={1993},
  volume={44 4},
  pages={795-804}
}
We investigated the effect of several immune-relevant cytokines on expression of the chemoattractant intercrine/chemokine RANTES in a mouse mesangial cell line (MMC). Fifty ng/ml recombinant tumor necrosis factor alpha (TNF alpha) induced a marked increase in RANTES transcripts after two hours. RANTES mRNA remained elevated for 24 to 48 hours after stimulation, and could be abolished by co-incubation with 30 micrograms/ml of a neutralizing rabbit anti-TNF alpha antibody. Protein expression of… CONTINUE READING

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