TNF-alpha-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis.

@article{Wolf2001TNFalphainducedEO,
  title={TNF-alpha-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis.},
  author={David I Wolf and Rupert Hallmann and Gabriele Sass and Michael Sixt and Sabine K{\"u}sters and Bastian Fregien and Francisco Javier Cubero and Gisa Tiegs},
  journal={Journal of immunology},
  year={2001},
  volume={166 2},
  pages={1300-7}
}
TNF-alpha has been clearly identified as central mediator of T cell activation-induced acute hepatic injury in mice, e.g., Con A hepatitis. In this model, liver injury depends on both TNFRs, i.e., the 55-kDa TNFR1 as well as the 75-kDa TNFR2. We show in this report that the hepatic TNFRs are not transcriptionally regulated, but are regulated by receptor shedding. TNF directly mediates hepatocellular death by activation of TNFR1 but also induces the expression of inflammatory proteins, such as… CONTINUE READING

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