TNF-alpha induced DNA damage in primary murine hepatocytes.


Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, usually arising from a background of chronic inflammatory disease. Tumor necrosis factor alpha (TNF-alpha) is a pro-inflammatory cytokine produced in response to tissue injury, endotoxin exposure or infection and TNF-alpha signalling in hepatocytes is associated with an increase in… (More)


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@article{Wheelhouse2003TNFalphaID, title={TNF-alpha induced DNA damage in primary murine hepatocytes.}, author={Nicholas M. Wheelhouse and Yuen-Sum Chan and Sheona E Gillies and Helen Caldwell and James A. Ross and David J. Harrison and Sandrine Prost}, journal={International journal of molecular medicine}, year={2003}, volume={12 6}, pages={889-94} }