TNF-alpha-independent IL-8 expression: alterations in bacterial challenge dose cause differential human monocytic cytokine response.

@article{Patrone2006TNFalphaindependentIE,
  title={TNF-alpha-independent IL-8 expression: alterations in bacterial challenge dose cause differential human monocytic cytokine response.},
  author={Julia Beth Patrone and Samuel Earl Bish and D. C. Stein},
  journal={Journal of immunology},
  year={2006},
  volume={177 2},
  pages={
          1314-22
        }
}
We examined the effects of different bacterial doses of Neisseria gonorrhoeae on the cytokine response of primary human monocytes. The data indicate that a low multiplicity of infection (MOI) challenge (MOI = 0.1) results in substantial production of IL-8 and other chemokines/cytokines, in the absence of significant TNF-alpha production. Positive control challenges (MOI = 10) induced levels of IL-8 that were comparable to the low MOI challenges, but now induced significant levels of TNF-alpha… CONTINUE READING

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