TNF-alpha inactivation of collagen receptors: implications for fibroblast function and fibrosis.

@article{Chou1996TNFalphaIO,
  title={TNF-alpha inactivation of collagen receptors: implications for fibroblast function and fibrosis.},
  author={Daniel H. Chou and Wen-Hui Lee and C A McCulloch},
  journal={Journal of immunology},
  year={1996},
  volume={156 11},
  pages={4354-62}
}
TNF-alpha inhibits collagen synthesis and at high concentrations stimulates collagenase synthesis in fibroblasts. As fluid from chronic inflammatory lesions contains significant levels of TNF-alpha, it is puzzling why these lesions exhibit dense accumulations of disorganized collagen. In this study we determined if low concentrations of TNF-alpha may inhibit the collagen phagocytic pathway in fibroblasts and thereby contribute to fibrosis. Collagen phagocytosis was measured by flow cytometric… CONTINUE READING
27 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Similar Papers

Loading similar papers…