TNF-alpha and TNF-beta gene polymorphisms in cerebral infarction.

  title={TNF-alpha and TNF-beta gene polymorphisms in cerebral infarction.},
  author={Jae-Young Um and Neeon-Hyung An and Hyung-Min Kim},
  journal={Journal of molecular neuroscience : MN},
  volume={21 2},
Tumor necrosis factor (TNF) is an important cytokine in the inflammation process of atherosclerosis. Two biallelic polymorphisms in the TNF-alpha (TNF-alpha -308) and TNF-beta (TNF-beta +252) genes have been reported to be associated with TNF production and susceptibility to inflammatory diseases. We investigated two genetic polymorphisms in the TNF locus (TNF-alpha -308 G-->A and TNF-beta +252 A-->G) as risk factors for cerebral infarction (CI) by determining its prevalence in 294 survivors of… CONTINUE READING
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