TNF-alpha and IL-1 beta-mediated regulation of MMP-9 and TIMP-1 in human glomerular mesangial cells.

@article{Nee2007TNFalphaAI,
  title={TNF-alpha and IL-1 beta-mediated regulation of MMP-9 and TIMP-1 in human glomerular mesangial cells.},
  author={Larine E Nee and Niamh Tuite and Michael P. Ryan and Tara McMorrow},
  journal={Nephron. Experimental nephrology},
  year={2007},
  volume={107 2},
  pages={e73-86}
}
BACKGROUND Renal cells such as mesangial cells are known to secrete metalloproteinases that are capable of degrading the constituents of the glomerular basement membrane (GBM). Disruption of the GBM via cytokine-induced alterations in matrixmetalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) may be an important mechanism in the renal disease process. In renal disease, both resident renal cells and infiltrating immune cells are capable of secreting pro-inflammatory… CONTINUE READING

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