TNF-alpha, but not IFN-gamma, regulates CCN2 (CTGF), collagen type I, and proliferation in mesangial cells: possible roles in the progression of renal fibrosis.

@article{Cooker2007TNFalphaBN,
  title={TNF-alpha, but not IFN-gamma, regulates CCN2 (CTGF), collagen type I, and proliferation in mesangial cells: possible roles in the progression of renal fibrosis.},
  author={Laurinda A Cooker and Darryl R Peterson and Joann Rambow and Melisa L. Riser and Rebecca E Riser and Feridoon Najmabadi and David R Brigstock and Bruce L. Riser},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={293 1},
  pages={F157-65}
}
Connective tissue growth factor (CCN2) is a profibrotic factor acting downstream and independently of TGF-beta to mediate renal fibrosis. Although inflammation is often involved in the initiation and/or progression of fibrosis, the role of inflammatory cytokines in regulation of glomerular CCN2 expression, cellular proliferation, and extracellular matrix accumulation is unknown. We studied two such cytokines, TNF-alpha and IFN-gamma, for their effects on cultured mesangial cells in the presence… CONTINUE READING
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CCN2 (CTGF) in the pathogenesis of diabetic renal disease: A target for therapeutic intervention, pp 175-186

  • B Riser, A Foroni, S. Karoor
  • 2005
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