TNF activates P-glycoprotein in cerebral microvascular endothelial cells.

@article{Yu2007TNFAP,
  title={TNF activates P-glycoprotein in cerebral microvascular endothelial cells.},
  author={Chuanhui Yu and Abba J. Kastin and Hong Hai Tu and Sarah Waters and Weihong Pan},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2007},
  volume={20 6},
  pages={853-8}
}
BACKGROUND/AIMS Multidrug resistance proteins (MDRs, including P-glycoproteins) are efflux pumps that serve important biological functions but hinder successful drug delivery to the CNS. Many chemotherapeutic agents, anti-epileptics, anti-HIV drugs, and opiates are substrates for MDRs. Therefore, understanding the regulation of MDRs in the endothelial cells composing the blood-brain barrier has therapeutic implications. METHODS We used microarray, real time RT-PCR, Western blotting, and… CONTINUE READING

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This suggests that adjunctive anti - TNF treatment has novel therapeutic potential in conditions such as brain cancer , epilepsy , neuroAIDS , and chronic pain .
This suggests that adjunctive anti - TNF treatment has novel therapeutic potential in conditions such as brain cancer , epilepsy , neuroAIDS , and chronic pain .
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