TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Armed Exosomes Deliver Proapoptotic Signals to Tumor Site.

  title={TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Armed Exosomes Deliver Proapoptotic Signals to Tumor Site.},
  author={Licia Rivoltini and Claudia Chiodoni and Paola Squarcina and Monica Tortoreto and Antonello Villa and Barbara Vergani and Maja B{\"u}rdek and L. Botti and Ivano Arioli and Agata Cova and Giorgio Mauri and Elisabetta Vergani and Beatrice Bianchi and Pamela Della Mina and Laura Cantone and Valentina Bollati and Nadia Zaffaroni and Alessandro Massimo Gianni and Mario P Colombo and Veronica Huber},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={22 14},
PURPOSE Exosomes deliver signals to target cells and could thus be exploited as an innovative therapeutic tool. We investigated the ability of membrane TRAIL-armed exosomes to deliver proapoptotic signals to cancer cells and mediate growth inhibition in different tumor models. EXPERIMENTAL METHODS AND RESULTS K562 cells, transduced with lentiviral human membrane TRAIL, were used for the production of TRAIL(+) exosomes, which were studied by nanoparticle tracking analysis, cytofluorimetry… CONTINUE READING
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  • LA Norian, TP Kresowik, HM Rosevear, BR James, TR Rosean, AJ Lightfoot
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  • 2016
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