TNF Receptor-2 Facilitates an Immunosuppressive Microenvironment in the Liver to Promote the Colonization and Growth of Hepatic Metastases.

@article{Ham2015TNFRF,
  title={TNF Receptor-2 Facilitates an Immunosuppressive Microenvironment in the Liver to Promote the Colonization and Growth of Hepatic Metastases.},
  author={Boram Ham and Ni Wang and Zarina J. D'Costa and Mar{\'i}a Celia Fern{\'a}ndez and France Bourdeau and Patrick Auguste and Martin Illemann and Rikke Loevendahl Eefsen and Gunilla H\oyer-Hansen and Ben Vainer and Maximilien Evrard and Zu-Hua Gao and Pnina Brodt},
  journal={Cancer research},
  year={2015},
  volume={75 24},
  pages={5235-47}
}
Successful colonization by a cancer cell of a distant metastatic site requires immune escape in the new microenvironment. TNF signaling has been implicated broadly in the suppression of immune surveillance that prevents colonization at the metastatic site and therefore must be blocked. In this study, we explored how TNF signaling influences the efficiency of liver metastasis by colon and lung carcinoma in mice that are genetically deficient for the TNF receptor TNFR2. We found a marked… CONTINUE READING