TNF-R1 Signaling: A Beautiful Pathway

@article{Chen2002TNFR1SA,
  title={TNF-R1 Signaling: A Beautiful Pathway},
  author={G. Chen and D. Goeddel},
  journal={Science},
  year={2002},
  volume={296},
  pages={1634 - 1635}
}
  • G. Chen, D. Goeddel
  • Published 2002
  • Medicine
  • Science
  • Tumor necrosis factor (TNF) is a major mediator of apoptosis as well as inflammation and immunity, and it has been implicated in the pathogenesis of a wide spectrum of human diseases, including sepsis, diabetes, cancer, osteoporosis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel diseases. The interaction of TNF with TNF receptor–1 (TNF-R1) activates several signal transduction pathways. A common feature of each pathway is the TNF-induced formation of a multiprotein signaling… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 1,303 CITATIONS, ESTIMATED 53% COVERAGE

    FILTER CITATIONS BY YEAR

    2002
    2020

    CITATION STATISTICS

    • 58 Highly Influenced Citations

    • Averaged 50 Citations per year from 2018 through 2020

    References

    Publications referenced by this paper.
    SHOWING 1-2 OF 2 REFERENCES

    Goeddel , TNF Pathway , Science ’ s STKE ( Connections Map , as seen May 2002 )

    TNF Pathway, Science’s STKE (Connections Map, as seen May 2002), http://stke. sciencemag.org/cgi/cm/CMP_7107

    • 2002
    VIEW 2 EXCERPTS