TNF-R1 Signaling: A Beautiful Pathway

  title={TNF-R1 Signaling: A Beautiful Pathway},
  author={G. Chen and D. Goeddel},
  pages={1634 - 1635}
Tumor necrosis factor (TNF) is a major mediator of apoptosis as well as inflammation and immunity, and it has been implicated in the pathogenesis of a wide spectrum of human diseases, including sepsis, diabetes, cancer, osteoporosis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel diseases. The interaction of TNF with TNF receptor–1 (TNF-R1) activates several signal transduction pathways. A common feature of each pathway is the TNF-induced formation of a multiprotein signaling… Expand
Signalling pathways of the TNF superfamily: a double-edged sword
  • B. Aggarwal
  • Medicine, Biology
  • Nature Reviews Immunology
  • 2003
Two different tumour-necrosis factors, first isolated in 1984, were found to be cytotoxic to tumour cells and to induce tumour regression in mice, and blockers of TNF have been approved for human use in treating TNF-linked autoimmune diseases. Expand
TNF and ROS Crosstalk in Inflammation.
Work aimed at defining the role of TNF in the control of ROS/RNS signaling that influences innate immune cells under both physiological and inflammatory conditions is summarized. Expand
TNF signaling: key protocols.
This chapter describes theAnalysis of the TNF receptor signaling complex by immunoprecipitation (IP), the activation of different MAP kinases by Western blot, the analysis of transcription factor activation by either electrophoretic mobility-shift assay (EMSA) or reporter assay, and theanalysis of TNF-induced genes by chromatin IP (ChIP). Expand
Regulation and dysregulation of tumor necrosis factor receptor-1.
Current knowledge of TNFR1 regulation is reviewed and the impact this has on the host is discussed, with a view to development of novel, safer or more effective drugs. Expand
Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors
It is found that soluble versions of PLAD, especially those derived from P60, block the biochemical effects of TNF-α in vitro and potently inhibit arthritis in animal models, suggesting that targeting the PLAD may have clinical value in the treatment of human arthritis. Expand
TNF-α signaling in Fanconi anemia.
The link between TNF-α signaling and FA pathway is discussed with emphasis on the implication of inflammation in the pathophysiology and abnormal hematopoiesis in FA. Expand
The role of TRADD in death receptor signaling
This review summarizes the recent advances in the field of DR signaling and in particular the role of TRADD. Expand
Regulation of TNFR1 and CD95 signalling by receptor compartmentalization
A role for receptor internalization and endosomal trafficking in selectively transmitting the signals that lead either to apoptosis or to the survival of the cell is revealed. Expand
TNF receptor superfamily‐induced cell death: redox‐dependent execution
  • Han-Ming Shen, S. Pervaiz
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2006
This work attempts to review the existing knowledge on the involvement of ROS in death receptor signaling using TNFα‐TNFR1 as the model system, specifically addressing the involved of intracellular ROS in TNF α‐induced cell death and in T NFα‐induced activation of NF‐κB and JNK and their crosstalk. Expand
TNF-α, a good or bad factor in hematological diseases?
The positive or negative role of TNF-α in hematological malignancies or diseases with a malignant tendency is evaluated and several studies have shown that inflammatory cytokines play an important role in the onset and progress of these diseases. Expand


Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?
Clinical investigations in which the activity of TNF alpha in RA patients was blocked with intravenously administered infliximab, a chimeric anti-TNF alpha monoclonal antibody (mAB), has provided evidence that TNF regulates IL-6, IL-8, MCP-1, and VEGF production, recruitment of immune and inflammatory cells into joints, angiogenesis, and reduction of blood levels of matrix metalloproteinases-1 and -3. Expand
The TNF and TNF Receptor Superfamilies Integrating Mammalian Biology
The authors regret the inability to cite all of the primary literature contributing to this review due to length considerations, but wish to thank F. Chan, T. Migone, and J. Wang for insightful comments on the manuscript. Expand
Missing Pieces in the NF-κB Puzzle
This review is focused on recent progress as well as unanswered questions regarding the regulation and function of NF-kappaB and IKK. Expand
TNF Pathway, Science’s STKE (Connections Map, as seen May 2002), http://stke.
  • 2002
Goeddel , TNF Pathway , Science ’ s STKE ( Connections Map , as seen May 2002 )