TNF-R1 Signaling: A Beautiful Pathway

@article{Chen2002TNFR1SA,
  title={TNF-R1 Signaling: A Beautiful Pathway},
  author={Guoqing Chen and David Norman Van Goeddel},
  journal={Science},
  year={2002},
  volume={296},
  pages={1634 - 1635}
}
Tumor necrosis factor (TNF) is a major mediator of apoptosis as well as inflammation and immunity, and it has been implicated in the pathogenesis of a wide spectrum of human diseases, including sepsis, diabetes, cancer, osteoporosis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel diseases. The interaction of TNF with TNF receptor–1 (TNF-R1) activates several signal transduction pathways. A common feature of each pathway is the TNF-induced formation of a multiprotein signaling… 

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