TNF Inhibition for Ophthalmic Indications: Current Status and Outlook

  title={TNF Inhibition for Ophthalmic Indications: Current Status and Outlook},
  author={Lana M. Rifkin and Andrea D. Birnbaum and D. Goldstein},
  • Lana M. Rifkin, Andrea D. Birnbaum, D. Goldstein
  • Published 2013
  • Medicine
  • BioDrugs
  • BackgroundTumor necrosis factors (TNF) are a group of cytokines that play a role in systemic inflammation, stimulating the acute phase reaction. They are involved in systemic rheumatologic conditions such as rheumatoid arthritis and juvenile idiopathic arthritis, as well as ocular inflammatory conditions in the uveitis spectrum. Several drugs were developed to inhibit the action of TNF, thereby reducing inflammation. The three most commonly used TNF inhibitors in the US are etanercept… CONTINUE READING
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