TNF-α up-regulates protein level and cell surface expression of the leptin receptor by stimulating its export via a PKC-dependent mechanism.

@article{Gan2012TNFUP,
  title={TNF-α up-regulates protein level and cell surface expression of the leptin receptor by stimulating its export via a PKC-dependent mechanism.},
  author={Lixia Gan and Kaiying Guo and Maria Laura Cremona and Timothy E McGraw and Rudolph L. Leibel and Yiying Zhang},
  journal={Endocrinology},
  year={2012},
  volume={153 12},
  pages={5821-33}
}
Increasing evidence suggests that inflammation/cytokines may modulate hypothalamic responses to leptin, which is a key regulator of energy homeostasis and inflammatory/stress responses. We investigated a possible role of TNF-α, a key early mediator of inflammation, in regulating the expression and trafficking of the long-isoform leptin receptor (LEPRb), the primary mediator of leptin signaling, in cultured cells. We found that TNF-α in a wide range of concentrations up-regulated LEPRb protein… CONTINUE READING

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