TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity

@inproceedings{Ramesh2002TNFMC,
  title={TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity},
  author={Ganesan Ramesh and W. Brian Reeves},
  year={2002}
}
Cisplatin is an effective chemotherapeutic agent used in the treatment of a wide variety of both pediatric and adult malignancies (1). Dose-dependent and cumulative nephrotoxicity is the major toxicity of this compound, sometimes requiring a reduction in dose or discontinuation of treatment. Approximately 25–35% of patients develop evidence of nephrotoxicity following a single dose of cisplatin (2). Much attention has been focused on the direct toxic effects of cisplatin in renal tubular cells… CONTINUE READING
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Tumor necrosis factor-alpha converting enzyme

  • R. A. Black
  • Int. J. Biochem. Cell Biol
  • 2002
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