TNF-α-induced endothelium-independent vasodilation: a role for phospholipase A2-dependent ceramide signaling.

@article{Johns1998TNFinducedEV,
  title={TNF-α-induced endothelium-independent vasodilation: a role for phospholipase A2-dependent ceramide signaling.},
  author={Douglas G. Johns and Robert Clinton Webb},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={1998},
  volume={275 5},
  pages={H1592-H1598}
}
Ceramide is a novel second messenger generated by hydrolysis of membrane sphingomyelin by a neutral sphingomyelinase (nSMase). Cytokines such as tumor necrosis factor-α (TNF-α) have been shown to increase intracellular ceramide through phospholipase A2(PLA2)-dependent activation of nSMase. TNF-α has been shown to cause endothelium-independent relaxation in isolated blood vessels. We have previously shown that exogenously applied sphingomyelinase and ceramide cause endothelium-independent… CONTINUE READING
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