TNF-α-induced down-regulation of CDX2 suppresses MEP1A expression in colitis.

  title={TNF-α-induced down-regulation of CDX2 suppresses MEP1A expression in colitis.},
  author={Mehmet Erdal Coskun and Anders Kr{\"u}ger Olsen and Thomas Lindebo Holm and Peter Helding Kvist and Ole Haagen Nielsen and Lene Buhl Riis and J\orgen L. Olsen and Jesper Thorvald Troelsen},
  journal={Biochimica et biophysica acta},
  volume={1822 6},
BACKGROUND/AIMS High levels of pro-inflammatory cytokines are linked to inflammatory bowel disease (IBD). The transcription factor Caudal-related homeobox transcription factor 2 (CDX2) plays a crucial role in differentiation of intestinal epithelium and regulates IBD-susceptibility genes, including meprin 1A (MEP1A). The aim was to investigate the expression of CDX2 and MEP1A in colitis; to assess if they are regulated by tumor necrosis factor-α (TNF-α), and finally to reveal if CDX2 is… CONTINUE READING