TNF-α impairs insulin signaling and insulin stimulation of glucose uptake in C2C12muscle cells.

@article{Aguila1999TNFII,
  title={TNF-α impairs insulin signaling and insulin stimulation of glucose uptake in C2C12muscle cells.},
  author={Luis F Del Aguila and Kevin P. Claffey and John P Kirwan},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={1999},
  volume={276 5},
  pages={E849-E855}
}
Physiological stressors such as sepsis and tissue damage initiate an acute immune response and cause transient systemic insulin resistance. This study was conducted to determine whether tumor necrosis factor-α (TNF-α), a cytokine produced by immune cells during skeletal muscle damage, decreases insulin responsiveness at the cellular level. To examine the molecular mechanisms associated with TNF-α and insulin action, we measured insulin receptor substrate (IRS)-1- and IRS-2-mediated… CONTINUE READING
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