TNF-α gene silencing using polymerized siRNA/thiolated glycol chitosan nanoparticles for rheumatoid arthritis.

@article{Lee2014TNFGS,
  title={TNF-α gene silencing using polymerized siRNA/thiolated glycol chitosan nanoparticles for rheumatoid arthritis.},
  author={Suyeong Lee and Aeju Lee and Seung Rim Hwang and Jong-Sung Park and Jiyeon Jang and Myung Sook Huh and Dong-Gyu Jo and Soo-Young Yoon and Youngro Byun and Sun Hwa Kim and Ick Chan Kwon and Inchan Youn and Kwangmeyung Kim},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2014},
  volume={22 2},
  pages={
          397-408
        }
}
Among various proinflammatory cytokines involved in the pathogenesis of rheumatoid arthritis (RA), tumor necrosis factor (TNF)-α plays a pivotal role in the release of other cytokines and induction of chronic inflammation. Even though siRNA has the therapeutic potential, they have a challenge to be delivered into the target cells because of their poor stability in physiological fluids. Herein, we design a nanocomplex of polymerized siRNA (poly-siRNA) targeting TNF-α with thiolated glycol… CONTINUE READING
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