TNF-α gene polymorphisms: association with disease susceptibility and response to anti-TNF-α treatment in psoriatic arthritis.

@article{Murdaca2014TNFGP,
  title={TNF-α gene polymorphisms: association with disease susceptibility and response to anti-TNF-α treatment in psoriatic arthritis.},
  author={Giuseppe Murdaca and Rossella Gulli and Francesca Span{\`o} and Francesca Lantieri and Martina Burlando and Aurora Parodi and Paola Mandich and F Puppo},
  journal={The Journal of investigative dermatology},
  year={2014},
  volume={134 10},
  pages={2503-2509}
}
The tumor necrosis factor-α (TNF-α) gene has been proposed as a major candidate gene in psoriatic arthritis (PsA). TNF-α is a therapeutic target for patients responding poorly to conventional treatments. We investigated the role of single-nucleotide polymorphisms (SNPs) at positions -238, -308, and +489 of the TNF-α gene in the genetic susceptibility to PsA, in the severity of the disease, and, finally, in the response to TNF-α inhibitors (adalimumab, etanercept, or infliximab). Fifty-seven… CONTINUE READING
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