TNF-α and serum induce SKALP/elafin gene expression in human keratinocytes by a p38 MAP kinase-dependent pathway

@article{Pfundt2000TNFAS,
  title={TNF-α and serum induce SKALP/elafin gene expression in human keratinocytes by a p38 MAP kinase-dependent pathway},
  author={Rolph Pfundt and Miriam Wingens and Mieke Bergers and Manon C. Zweers and Marijke Frenken and Joost Schalkwijk},
  journal={Archives of Dermatological Research},
  year={2000},
  volume={292},
  pages={180-187}
}
Keratinocytes of inflamed epidermis (psoriasis, wound healing) are hyperproliferative and display an abnormal differentiation programme. This regenerative differentiation pathway is characterized by the induction of genes that are not expressed by keratinocytes in normal skin, such as the cytokeratins CK6, CK16, CK17, and the proteinase inhibitor SKALP/elafin. In the study reported here we investigated the induction and regulation of SKALP expression as a marker for regenerative differentiation… CONTINUE READING