TNF-α and its receptors modulate complex behaviours and neurotrophins in transgenic mice

@article{Camara2013TNFAI,
  title={TNF-α and its receptors modulate complex behaviours and neurotrophins in transgenic mice},
  author={Marie lou Camara and Frances Corrigan and Emily Joy Jaehne and Magdalene C. Jawahar and Bernhard T. Baune},
  journal={Psychoneuroendocrinology},
  year={2013},
  volume={38},
  pages={3102-3114}
}
UNLABELLED Tumour necrosis factor-α (TNF-α) plays an important role not only in immunity but also in the normal functioning of the central nervous system (CNS). At physiological levels, studies have shown TNF-α is essential to maintain synaptic scaling and thus influence learning and memory formation while also playing a role in modulating pathological states of anxiety and depression. TNF-α signals mainly through its two receptors, TNF-R1 and TNF-R2, however the exact role that these receptors… CONTINUE READING

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Tumour necrosis factor alpha mediated mechanisms of cognitive dysfunction

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  • Trends Neurosci
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