TNF-α and insulin resistance: Summary and future prospects

@article{Peraldi2004TNFAI,
  title={TNF-$\alpha$ and insulin resistance: Summary and future prospects},
  author={Pascal Peraldi and Bruce M Spiegelman},
  journal={Molecular and Cellular Biochemistry},
  year={2004},
  volume={182},
  pages={169-175}
}
While the causes of obesity remain elusive, the relationship between obesity and insulin resistance is a well-established fact [1]. Insulin resistance is defined as a smaller than normal response to a certain dose of insulin, and contributes to several pathological problems of obese patients such as hyperlipidemia, arteriosclerosis and hypertension. Several pieces of evidence indicate that the cytokine tumor necrosis factor a (TNF-α) is an important player in the state of insulin resistance… 

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