TNF-α and insulin resistance: Summary and future prospects
@article{Peraldi2004TNFAI, title={TNF-$\alpha$ and insulin resistance: Summary and future prospects}, author={Pascal Peraldi and Bruce M Spiegelman}, journal={Molecular and Cellular Biochemistry}, year={2004}, volume={182}, pages={169-175} }
While the causes of obesity remain elusive, the relationship between obesity and insulin resistance is a well-established fact [1]. Insulin resistance is defined as a smaller than normal response to a certain dose of insulin, and contributes to several pathological problems of obese patients such as hyperlipidemia, arteriosclerosis and hypertension. Several pieces of evidence indicate that the cytokine tumor necrosis factor a (TNF-α) is an important player in the state of insulin resistance…
139 Citations
The role of TNF-α in insulin resistance
- Medicine, Biology
- 2004
This review will discuss the regulation of insulin responses by TNF-α and evidence supporting the hypothesis that over expression of T NF-α plays a role in the pathophysiology of insulin resistance, and discuss the role of fat, especially visceral fat, as an endocrine organ.
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Circulating levels of adipokines vary in obesity and adiponectin and visfatin are associated with obesity.
Changes in serum adipokines profile and insulin resistance in patients with rheumatoid arthritis treated with anti-TNF-α
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Anti-TNF-α agents could have a crucial role in modifying the impact of lipid profile and glucose levels dysregulation in RA patients and may be a potential strategy for the prevention of metabolic syndrome.
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