TNF-α and insulin resistance: Summary and future prospects

@article{Peraldi2004TNFAI,
  title={TNF-$\alpha$ and insulin resistance: Summary and future prospects},
  author={Pascal Peraldi and Bruce M Spiegelman},
  journal={Molecular and Cellular Biochemistry},
  year={2004},
  volume={182},
  pages={169-175}
}
While the causes of obesity remain elusive, the relationship between obesity and insulin resistance is a well-established fact [1]. Insulin resistance is defined as a smaller than normal response to a certain dose of insulin, and contributes to several pathological problems of obese patients such as hyperlipidemia, arteriosclerosis and hypertension. Several pieces of evidence indicate that the cytokine tumor necrosis factor a (TNF-α) is an important player in the state of insulin resistance… 
View on Springer
139 Citations
Highly Influential Citations
1
Background Citations
28
Results Citations
2

Figures from this paper

139 Citations

Citation Type

Citation Type

The role of TNF-α in insulin resistance
TLDR
This review will discuss the regulation of insulin responses by TNF-α and evidence supporting the hypothesis that over expression of T NF-α plays a role in the pathophysiology of insulin resistance, and discuss the role of fat, especially visceral fat, as an endocrine organ.
Plasma Tumor Necrosis Factor-Alpha Levels and Insulin Resistance in Nondiabetic Hypertensive Subjects
TLDR
It is revealed that hypertensive patients have insulin resistance and higher TNF-α levels, but there is no relation between TNF -α levels and insulin resistance.
Serum tumor necrosis factor-alpha levels and components of the metabolic syndrome in obese adolescents.
Relationship between serum resistin concentration and proinflammatory cytokines in obese women with impaired and normal glucose tolerance.
Identifying the links between obesity, insulin resistance and β‐cell function: potential role of adipocyte‐derived cytokines in the pathogenesis of type 2 diabetes
TLDR
The anti‐inflammatory activity of the thiazolidinedione anti‐diabetic agents is potentially beneficial, given the possible role of pro‐inflammatory cytokines in linking insulin resistance with β‐cell dysfunction.
Role of the Adipocyte in Type 2 Diabetes
TLDR
The conclusions drawn from this research implicate the adipocyte as a central player in the development of insulin resistance, affecting muscle and liver of individuals with excess adipose tissue, and attention is given to the nuclear hormone receptor PPAR-γ (peroxisome proliferator-activated receptor γ) which is a master regulator of adipocyte differentiation and the target of the thiazolidinedione family of antidiabetic drugs.
Metabolic Syndrome and Inflammation
TLDR
The evolving concept of insulin resistance, type 2 diabetes and hypertension as having common inflammatory components provides new opportunities for developing strategies, currently underway, to correct the metabolic consequences of metabolic syndrome and chronic inflammation.
Association of adipokines with obesity in children and adolescents.
TLDR
Circulating levels of adipokines vary in obesity and adiponectin and visfatin are associated with obesity.
Adipokines and dementia
Changes in serum adipokines profile and insulin resistance in patients with rheumatoid arthritis treated with anti-TNF-α
TLDR
Anti-TNF-α agents could have a crucial role in modifying the impact of lipid profile and glucose levels dysregulation in RA patients and may be a potential strategy for the prevention of metabolic syndrome.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 80 REFERENCES
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.
TLDR
A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated.
Tumor necrosis factor alpha inhibits signaling from the insulin receptor.
TLDR
Results show that TNF-alpha directly interferes with the signaling of insulin through its receptor and consequently blocks biological actions of insulin.
Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.
TLDR
It is demonstrated that TNF-alpha participates in obesity-related systemic insulin resistance by inhibiting the IR tyrosine kinase in the two tissues mainly responsible for insulin-stimulated glucose uptake: muscle and fat.
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
TLDR
A role for the abnormal regulation of this cytokine in the pathogenesis of obesity-related insulin resistance is suggested as well as the effects of weight reduction by dietary treatment of obesity on the adipose expression of TNF-alpha mRNA.
Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance.
TLDR
Results indicate that gene expression for the TNF systems can be regulated by an insulin-sensitizing drug and reduction of body weight, and support a role for this cytokine in the insulin-resistant diabetic state.
The expression of TNF alpha by human muscle. Relationship to insulin resistance.
TLDR
TNF is expressed in human muscle, and is expressed at a higher level in the muscle tissue and in the cultured muscle cells from insulin resistant and diabetic subjects, which suggest another mechanism by which TNF may play an important role in human insulin resistance.
Effects of an Engineered Human Anti–TNF-α Antibody (CDP571) on Insulin Sensitivity and Glycemic Control in Patients With NIDDM
TLDR
TNF-α neutralization over a period of 4 weeks had no effect on insulin sensitivity in obese NIDDM subjects and C-peptide remained unaffected by the type of treatment throughout the study.
IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance
TLDR
Results indicate that TNF-α induces insulin resistance through an unexpected action of IRS-1 to attenuate insulin receptor signaling.
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.
TLDR
The data suggest that endogenous TNF expression in adipose tissue may help limit obesity in some subjects, perhaps by increasing insulin resistance and decreasing LPL.
Tumor necrosis factor-alpha- and hyperglycemia-induced insulin resistance. Evidence for different mechanisms and different effects on insulin signaling.
TLDR
The data suggest that TNF-alpha and high glucose modulate insulin receptor-signaling through different mechanisms: (a) T NF-alpha modulates insulin receptor signals by PTPase activation, whereas glucose acts through activation of PKC.
...
1
2
3
4
5
...