TNF-α Producing Innate Lymphoid Cells (ILCs) Are Increased in Active Celiac Disease and Contribute to Promote Intestinal Atrophy in Mice

@inproceedings{Marafini2015TNFPI,
  title={TNF-α Producing Innate Lymphoid Cells (ILCs) Are Increased in Active Celiac Disease and Contribute to Promote Intestinal Atrophy in Mice},
  author={Irene Marafini and Ivan Monteleone and Davide Di Fusco and Maria Laura Cupi and Omero Alessandro Paoluzi and Alfredo Colantoni and Angela Ortenzi and Roberta Izzo and Simone Vita and Elisabetta De Luca and Giuseppe Sica and Francesco Pallone and Giovanni Monteleone},
  booktitle={PloS one},
  year={2015}
}
Innate lymphoid cells (ILCs) are an emerging family of innate hematopoietic cells producing inflammatory cytokines and involved in the pathogenesis of several immune-mediated diseases. The aim of this study was to characterize the tissue distribution of ILCs in celiac disease (CD), a gluten-driven enteropathy, and analyze their role in gut tissue damage. ILC subpopulations were analyzed in lamina propria mononuclear cells (LPMCs) isolated from duodenal biopsies of CD patients and healthy… CONTINUE READING
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