TNF-α –308 G>A and –238 G>A polymorphisms are not major risk factors in Caucasian patients with exfoliation glaucoma

@article{Mossboeck2009TNFG,
  title={TNF-α –308 G>A and –238 G>A polymorphisms are not major risk factors in Caucasian patients with exfoliation glaucoma},
  author={Georg Mossboeck and Wilfried Renner and Yosuf El-Shabrawi and Christoph W Faschinger and Otto Schmut and Andreas Wedrich and Christina Zimmermann and Martin Weger},
  journal={Molecular Vision},
  year={2009},
  volume={15},
  pages={518 - 522}
}
PURPOSE TNF-alpha has been suggested to participate in the pathogenesis of exfoliation glaucoma (XFG). The purpose of the present study was to investigate a hypothesized association between two common functional polymorphisms in the promoter region of the TNF-alpha gene (TNF-alpha -308 G>A, rs1800629, and TNF-alpha -238 G>A, rs361525) and the presence of XFG in a Caucasian population. METHODS The present case-control study comprised 408 participants (204 patients with XFG and 204 control… CONTINUE READING

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