TNF-α/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells

@article{Oshima2014TNFTNFR1SP,
  title={TNF-α/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells},
  author={Hiroko Oshima and T. Ishikawa and Go J Yoshida and Kuniko Naoi and Yusuke Maeda and Kazuhito Naka and Xiaoli Ju and Yoshihiro Yamada and Toshinari Minamoto and Naofumi Mukaida and Hideyuki Saya and Masanobu Oshima},
  journal={Oncogene},
  year={2014},
  volume={33},
  pages={3820-3829}
}
Helicobacter pylori infection induces chronic inflammation that contributes to gastric tumorigenesis. Tumor necrosis factor (TNF-α) is a proinflammatory cytokine, and polymorphism in the TNF-α gene increases the risk of gastric cancer. We herein investigated the role of TNF-α in gastric tumorigenesis using Gan mouse model, which recapitulates human gastric cancer development. We crossed Gan mice with TNF-α (Tnf) or TNF-α receptor TNFR1 (Tnfrsf1a) knockout mice to generate Tnf−/− Gan and… CONTINUE READING

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