TNF-{alpha}, chronic hepatitis C and diabetes: a novel triad.

  title={TNF-\{alpha\}, chronic hepatitis C and diabetes: a novel triad.},
  author={Hy Knobler and Amichai Schattner},
  journal={QJM : monthly journal of the Association of Physicians},
  volume={98 1},
Patients with chronic hepatitis C virus (HCV) infection have a significantly increased prevalence of type 2 DM compared to controls or HBV-infected patients, independent of the presence of cirrhosis. Moreover, antecedent HCV infection markedly increases the risk of developing DM in susceptible subjects. Even non-diabetic HCV patients have insulin resistance and specific defects in the insulin-signalling pathway. Activation of the tumour necrosis factor (TNF)-alpha system has a pivotal role in… CONTINUE READING


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