TNF‐α‐inducing protein, a carcinogenic factor secreted from H. pylori, enters gastric cancer cells

  title={TNF‐α‐inducing protein, a carcinogenic factor secreted from H. pylori, enters gastric cancer cells},
  author={M. Suganuma and K. Yamaguchi and Y. Ono and Haruo Matsumoto and T. Hayashi and T. Ogawa and K. Imai and T. Kuzuhara and A. Nishizono and H. Fujiki},
  journal={International Journal of Cancer},
  • M. Suganuma, K. Yamaguchi, +7 authors H. Fujiki
  • Published 2008
  • Biology, Medicine
  • International Journal of Cancer
  • TNF‐α inducing protein (Tipα) is secreted from Helicobacter pylori (H. pylori): it is a potent inducer of TNF‐α and chemokine genes, mediated through NF‐κB activation, and it also induces tumor‐promoting activity in Bhas 42 cells. To investigate the carcinogenic mechanisms of H. pylori with Tipα, we first examined how Tipα acts on gastric epithelial cells. We found that fluorescent‐Tipα specifically bound to, and then entered, the cells in a dose‐ and temperature‐dependent manner, whereas… CONTINUE READING
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