TNFα up-regulates COX-2 in chronic progressive nephropathy through nuclear accumulation of RelB and NF-κB2.

Abstract

OBJECTIVE The pathogenesis of progressive nephropathies involves inflammatory factors. The inhibition of cyclooxygenase-2 (COX-2) can limit renal damage and inflammation. However, the mechanism of up-regulation of COX-2 in nephropathy is poorly defined. MATERIALS AND METHODS Here we found that tumor necrosis factor alpha (TNFα) was involved in expression… (More)
DOI: 10.3109/13813455.2016.1141961

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