TNFα reverse signaling promotes sympathetic axon growth and target innervation

@inproceedings{Kisiswa2013TNFRS,
  title={TNFα reverse signaling promotes sympathetic axon growth and target innervation},
  author={Lilian Kisiswa and Catarina Os{\'o}rio and Clara Erice and Thomas N. Vizard and Sean L. Wyatt and Alun M Davies},
  booktitle={Nature Neuroscience},
  year={2013}
}
Reverse signaling via members of the tumor necrosis factor (TNF) superfamily controls multiple aspects of immune function. Here we document TNFα reverse signaling in the nervous system to our knowledge for the first time and show that it has a crucial role in establishing sympathetic innervation. During postnatal development, sympathetic axons express TNFα as they grow and branch in their target tissues, which in turn express TNF receptor 1 (TNFR1). In culture, soluble forms of TNFR1 act… CONTINUE READING
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