TNFα regulation of Fas ligand expression on the vascular endothelium modulates leukocyte extravasation

Abstract

It is generally believed that the vascular endothelium serves as an inflammatory barrier by providing a nonadherent surface to leukocytes. Here, we report that Fas ligand (FasL) is expressed on vascular endothelial cells (ECs) and that it may function to actively inhibit leukocyte extravasation. TNFα downregulates FasL expression with an accompanying… (More)
DOI: 10.1038/nm0498-415

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