TNFα receptor genotype influences smoking-induced muscle-fibre-type shift and atrophy in mice

  title={TNFα receptor genotype influences smoking-induced muscle-fibre-type shift and atrophy in mice},
  author={Boel de Paepe and Guy G Brusselle and Tania Maes and Kim K. Creus and Sophie D’hose and Nele D’Haese and Ken R Bracke and An I. D’hulst and Guy F Joos and Jan L. De Bleecker},
  journal={Acta Neuropathologica},
Systemic manifestations of chronic obstructive pulmonary disease (COPD) include muscle wasting, and tumour necrosis factor α (TNFα) could represent a major inducer of these processes. We studied skeletal muscle histology in a murine model of cigarette smoke (CS)-induced COPD, comparing mice with different TNFα receptor genotypes. Muscles from hind limbs of wild type (WT), TNFα receptor 1 knockout (TNFαR1KO) and TNFαR2KO mice were prepared and weighed. The lower body weight, which was observed… CONTINUE READING


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