TNFα-mediated cell death is independent of Cdc25A

@article{Krupitza1998TNFmediatedCD,
  title={TNFα-mediated cell death is independent of Cdc25A},
  author={G Krupitza and Michael Grusch and Katja Braun and Gerhard Fuhrmann and Richard Steinbrugger and Wolfgang Hulla and Ingrid Simonitsch and Andreas Chott and Markus Hengstschlaeger},
  journal={Cell Death and Differentiation},
  year={1998},
  volume={5},
  pages={758-764}
}
Tumor necrosis factor (TNFs) have been shown to be synthesized by ovarian carcinomas, and may therefore affect tumor cells in an autocrine manner. Therefore, we investigated the effects of recombinant TNFs on ovarian carcinoma cells N.1 and examined expression of the proto-oncogenes c-myc and cdc25A which are known to play a prominent role in apoptosis.  TNFα elicited apoptosis in N.1 cells within 72 h which was shown by typical morphological changes, DNA fragmentation and signature type… CONTINUE READING

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