TNFα-induced DLK activation contributes to apoptosis in the beta-cell line HIT

@article{Brchers2017TNFinducedDA,
  title={TNFα-induced DLK activation contributes to apoptosis in the beta-cell line HIT},
  author={Svenja B{\"o}rchers and Rohollah Babaei and Catarina Klimpel and Jorge Duque Escobar and Sabine Schr{\"o}der and Roland Blume and Muhammad H. Malik and Elke Oetjen},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2017},
  volume={390},
  pages={813-825}
}
Reduction in beta-cell mass and function contributes to the pathogenesis of diabetes mellitus type 2. The proinflammatory cytokines tumor necrosis factor (TNF)α and interleukin (IL)-1β have been implicated in the pathogenesis of this disease. Overexpression of the dual leucine zipper kinase (DLK) inhibits beta-cell function and induces apoptosis in the beta-cell line HIT. In the present study, it was investigated whether TNFα or IL-1β stimulates DLK enzymatic activity. Immunoblot analysis… CONTINUE READING

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