TNFα and reactive oxygen species in necrotic cell death

@article{Morgan2008TNFAR,
  title={TNFα and reactive oxygen species in necrotic cell death},
  author={Michael J. Morgan and You-sun Kim and Zheng-gang Liu},
  journal={Cell Research},
  year={2008},
  volume={18},
  pages={343-349}
}
Death receptors, including the TNF receptor-1 (TNF-RI), have been shown to be able to initiate caspase-independent cell death. This form of “necrotic cell death” appears to be dependent on the generation of reactive oxygen species. Recent data have indicated that superoxide generation is dependent on the activation of NADPH oxidases, which form a complex with the adaptor molecules RIP1 and TRADD. The mechanism of superoxide generation further establishes RIP1 as the central molecule in ROS… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 73 REFERENCES

Implica - tion of cytosolic phospholipase A 2 ( cPLA 2 ) in the regulation of human synoviocyte NADPH oxidase ( Nox 2 ) activity

C Chenevier-Gobeaux, C Simonneau, P Therond
  • Life Sci
  • 2007

A specific p 47 phoxserine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites

PM Dang, A Stensballe, T Boussetta
  • J Clin Invest
  • 2006

Butylated hydroxyanisole is more than a reactive oxygen species scavenger

N Festjens, M Kalai, +4 authors P Vandenabeele
  • Cell Death and Differentiation
  • 2006