TNFα alters occludin and cerebral endothelial permeability: Role of p38MAPK

Abstract

Occludin is a key tight junction (TJ) protein in cerebral endothelial cells (CECs) playing an important role in modulating blood-brain barrier (BBB) functions. This protein (65kDa) has been shown to engage in many signaling pathways and phosphorylation by both tyrosine and threonine kinases. Despite yet unknown mechanisms, pro-inflammatory cytokines and… (More)
DOI: 10.1371/journal.pone.0170346

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