TNFα Decreases Gluconeogenesis in Hepatocytes Isolated from 10-Day-Old Rats

@article{Goto2001TNFDG,
  title={TNFα Decreases Gluconeogenesis in Hepatocytes Isolated from 10-Day-Old Rats},
  author={Masakatsu Goto and Toyokazu Yoshioka and Tadej Battelino and Thyyar M Ravindranath and William P. Zeller},
  journal={Pediatric Research},
  year={2001},
  volume={49},
  pages={552-557}
}
Gluconeogenesis decreases during septic shock, but its mechanism is not well known. Tumor necrosis factor alpha (TNF-α), which is a key cytokine in septic shock, can increase GLUT1 gene expression and glucose uptake in muscles and fatty tissues. TNF-α does not alter the metabolism of hepatocytes in which GLUT2 is the predominant glucose transporter. However, GLUT1 is the predominant glucose transporter in hepatocytes of 10-d-old rats. Thus, we hypothesized that TNF-α might increase glucose… CONTINUE READING