TNFα Cooperates with IFN-γ to Repress Bcl-xL Expression to Sensitize Metastatic Colon Carcinoma Cells to TRAIL-mediated Apoptosis

@article{Liu2011TNFCW,
  title={TNFα Cooperates with IFN-γ to Repress Bcl-xL Expression to Sensitize Metastatic Colon Carcinoma Cells to TRAIL-mediated Apoptosis},
  author={F. Liu and X. Hu and M. Zimmerman and J. Waller and P. Wu and A. Hayes-Jordan and D. Lev and K. Liu},
  journal={PLoS ONE},
  year={2011},
  volume={6}
}
  • F. Liu, X. Hu, +5 authors K. Liu
  • Published 2011
  • Medicine, Biology
  • PLoS ONE
  • Background TNF-related apoptosis-inducing ligand (TRAIL) is an immune effector molecule that functions as a selective anti-tumor agent. However, tumor cells, especially metastatic tumor cells often exhibit a TRAIL-resistant phenotype, which is currently a major impediment in TRAIL therapy. The aim of this study is to investigate the synergistic effect of TNFα and IFN-γ in sensitizing metastatic colon carcinoma cells to TRAIL-mediated apoptosis. Methodology/Principal Findings The efficacy and… CONTINUE READING
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