TNFα Cooperates with IFN-γ to Repress Bcl-xL Expression to Sensitize Metastatic Colon Carcinoma Cells to TRAIL-mediated Apoptosis

@inproceedings{Liu2011TNFCW,
  title={TNFα Cooperates with IFN-γ to Repress Bcl-xL Expression to Sensitize Metastatic Colon Carcinoma Cells to TRAIL-mediated Apoptosis},
  author={Fei-yan Liu and Xiaolin Hu and Mary A Zimmerman and Jennifer L Waller and Ping Wu and Andrea Hayes-Jordan and Dina Chelouche Lev and Kebin Liu},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND TNF-related apoptosis-inducing ligand (TRAIL) is an immune effector molecule that functions as a selective anti-tumor agent. However, tumor cells, especially metastatic tumor cells often exhibit a TRAIL-resistant phenotype, which is currently a major impediment in TRAIL therapy. The aim of this study is to investigate the synergistic effect of TNFα and IFN-γ in sensitizing metastatic colon carcinoma cells to TRAIL-mediated apoptosis. METHODOLOGY/PRINCIPAL FINDINGS The efficacy and… CONTINUE READING

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