TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection.

Abstract

Respiratory infection with highly pathogenic influenza A viruses is characterized by the exuberant production of cytokines and chemokines and the enhanced recruitment of innate inflammatory cells. Here, we show that challenging mice with virulent influenza A viruses, including currently circulating H5N1 strains, causes the increased selective accumulation… (More)
DOI: 10.1073/pnas.0900655106

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