TNF/TNF-R1 pathway is involved in doxorubicin-induced acute sterile inflammation

Dear Editor, Doxorubicin is an anthracycline antibiotic, which is used in treatment of cancer and it works by induction of apoptosis in cancerous cells. In vivo, apoptotic cells are rapidly cleared preferentially by monocytes and neutrophil migration is inhibited to limit tissue injury and inflammation. More recently, few anti-cancer drugs, including… (More)