TMV-peptide fusion vaccines induce cell-mediated immune responses and tumor protection in two murine models.

@article{McCormick2006TMVpeptideFV,
  title={TMV-peptide fusion vaccines induce cell-mediated immune responses and tumor protection in two murine models.},
  author={Alison A McCormick and Tina A Corbo and Sherri Wykoff-Clary and Long Vo Nguyen and Mark R. Smith and Kenneth E. Palmer and Gregory P. Pogue},
  journal={Vaccine},
  year={2006},
  volume={24 40-41},
  pages={
          6414-23
        }
}
Fusion of peptides to viral carriers has proven an effective method for improving cellular immunity. In this study we explore the ability of a plant virus, Tobacco mosaic virus (TMV), to stimulate cellular immunity by interacting directly with immune cells. Fluorescently labeled TMV was incubated in vitro with murine spleen or lymph node cells, and near quantitative labeling of lymphocytes was achieved after 2 h, which persisted for up to 48 h. Direct TMV uptake and upregulation of the CD86… CONTINUE READING
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