TMS Produces Two Dissociable Types of Speech Disruption

  title={TMS Produces Two Dissociable Types of Speech Disruption},
  author={Lauren Stewart and Vincent Walsh and Uta Frith and John C. Rothwell},
We aimed to use repetitive transcranial magnetic stimulation (rTMS) to disrupt speech with the specific objective of dissociating speech disruption according to whether or not it was associated with activation of the mentalis muscle. Repetitive transcranial magnetic stimulation (rTMS) was applied over two sites of the right and left hemisphere while subjects counted aloud and recited the days of the week, months of the year, and nursery rhymes. Analysis of EMG data and videotaped recordings… 

Figures from this paper

Specific and nonspecific effects of transcranial magnetic stimulation on picture–word verification
It is demonstrated that low frequency rTMS has both general arousing effects and domain‐specific effects, and superimposed there were opposite effects on picture–word verification for stimulation of Wernicke's and Broca's area.
Covert Speech Arrest Induced by rTMS over Both Motor and Nonmotor Left Hemisphere Frontal Sites
Results show that rTMS can induce a covert SA when applied to areas over the brain that are pertinent to language, and both the left posterior/motor site and the left anterior/IFG site appear to be essential to language elaboration even when motor output is not required.
Repetitive Transcranial Magnetic Stimulation Affects behavior by Biasing Endogenous Cortical Oscillations
A governing assumption about repetitive transcranial magnetic stimulation (rTMS) has been that it interferes with task-related neuronal activity – in effect, by “injecting noise” into the brain – and
Stimulating language: insights from TMS.
Fifteen years ago, Pascual-Leone and colleagues used transcranial magnetic stimulation (TMS) to investigate speech production in pre-surgical epilepsy patients and in doing so, introduced a novel
Repetitive Transcranial Magnetic Stimulation of Broca's Area Affects Verbal Responses to Gesture Observation
It is proposed that Broca's area is involved in the process of translating into speech aspects concerning the social intention coded by the gesture, to support the theory that spoken language as evolved from an ancient communication system using arm gestures.
Transcranial magnetic stimulation and motor evoked potentials in speech perception research
It is suggested that future research may benefit from using TMS in conjunction with neuroimaging methods such as functional Magnetic Resonance Imaging or electroencephalography, and from the development of new stimulation protocols addressing cortico-cortical inhibition/facilitation and interhemispheric connectivity during speech processing.
Are there excitability changes in the hand motor cortex during speech in left-handed subjects?
Speech dominancy was localized primarily in the right cerebral hemisphere in left-handed subjects, but some individuals exhibited bilateral or left dominance, possibly attributable to the forced change of hand preference for writing in childhood.


Facilitation of picture naming after repetitive transcranial magnetic stimulation
Repetitive transcranial magnetic stimulation over Wernicke’s area leads to a brief facilitation of picture naming by shortening linguistic processing time.
Optimum stimulus parameters for lateralized suppression of speech with magnetic brain stimulation
The relative comfort and safety of stimulation at 4 Hz should allow more widespread use of magnetic speech localization in clinical and research applications.
Rapid‐rate transcranial magnetic stimulation and hemispheric language dominance
In the experience, r-TMS is not as sensitive as previously reported for determination of hemispheric language dominance and may have undesirable side effects.
Vocalization and arrest of speech.
Observations on vocalization as a response to stimulation of the human cerebral cortex and arrest of speech by means of stimulation are supplemented with limited reference to the effect of excision of areas of the sensorimotor convolutions in the dominant or the nondominant hemisphere.
Cortical language localization in left, dominant hemisphere. An electrical stimulation mapping investigation in 117 patients.
There is a need for revision of the classical model of language localization, for it means that language cannot be reliably localized on anatomic criteria alone and a maximal resection with minimal risk of postoperative aphasia requires individual localization of language with a technique like stimulation mapping.
Brain organization for language from the perspective of electrical stimulation mapping
  • G. Ojemann
  • Psychology
    Behavioral and Brain Sciences
  • 1983
Abstract A model for the organization of language in the adult humans brain is derived from electrical stimulation mapping of several language-related functions: naming, reading, short-term verbal
Transcranial magnetic stimulation. Its role in the evaluation of patients with partial epilepsy
The preliminary results with TRMS suggest that it may be used in the study of speech lateralization and that TMS is neither sensitive nor specific as an activation procedure of the epileptic focus in patients with partial epilepsy.
Interhemispheric transmission of information in manual and verbal reaction-time tasks.
It is concluded that the right field superiority observed with verbal stimuli is due to the processing of the input, and is independent of the verbal or non-verbal nature of the output.
Transcranial magnetic stimulation: a new investigational and treatment tool in psychiatry.
Transcranial magnetic stimulation represents an exciting new frontier in neuroscience research, providing insights into the pathophysiology and treatment of various neuropsychiatric disorders.